Omega-3 fatty acids and brain development

The brain is enriched in polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA) and arachidonic acid (ARA), PUFAs of the omega-3 and omega-6 series, respectively. Maternal fish intake during pregnancy is positively associated with beneficial effects on child neurodevelopment, and low omega-3 PUFA intakes are associated with increased risk of preterm and early birth. Long-chain omega-3 PUFAs are important across all stages of neurodevelopment, including neurogenesis, cell migration and maturation, synaptogenesis, and synaptic pruning, but the essential role of long-chain omega-6 PUFAs must also be appreciated. Foetal demand for DHA and ARA is high, especially in the last trimester, the period of maximal brain growth, and where more than 90% of foetal fat deposition occurs. Consequently, preterm infants are at risk of low levels of DHA and ARA intake, putting them at risk of a long-chain PUFA gap of prematurity.

This webinar will present a summary of the evidence and highlights from recent studies for each of these topics. Overall, this webinar will highlight many of the latest studies in the area and provide new perspectives to viewers with some existing knowledge, but it is also suitable for those who are new to the topic.

What will I gain from this webinar?

• Be able to describe omega-3 and omega-6 PUFA biosynthesis and the different classes of oxylipins.
• Be able to critically discuss the role of long-chain PUFAs in the neurodevelopmental process and the LCPUFA gap of prematurity.
• Provide an understanding of recent research into the role of omega-3 PUFAs in maternity and early life, and the evidence for decreasing the risk of preterm birth.